Zingiber mioga Extract Improves Moisturization and Depigmentation of Skin and Reduces Wrinkle Formation in UVB-Irradiated HRM-2 Hairless Mice

Here, we investigated the effects of Zingiber mioga extracts (FSH-ZM) on moisturization and depigmentation skin as well wrinkle formation in UVB-irradiated HRM-2 hairless mice. The mice were divided into six groups follows: normal control (NC), (C), positive 1 (PC1, L-ascorbic acid 200 mg/kg b.w.), 2 (PC2, Arbutin Z100 (FSH-ZM 100 Z200 b.w.). experiment spanned a period 6 weeks. We found that FSH-ZM led to an increase expression hyaluronan synthase 2, fibrillin-1, elastin mRNAs, showed improved hydration compared group. Furthermore, also inhibited inflammatory cytokines forming factors generated by UVB reduced wrinkles test group relative increasing collagen synthesis. Moreover, decreased melanogenesis factors, which These results suggest can potentially be utilized develop products aimed at improving reducing formation.